Wang (2020)
Coronavirus disease 2019 in elderly patients: Characteristics and prognostic factors based on 4-week follow-up
https://doi.org/10.1016/j.jinf.2020.03.019
https://www.ncbi.nlm.nih.gov/pubmed/32240670
Comorbidities
Cardiovascular disease (Present vs. Not present)
COVID-19 (death)
Hazard ratio: 1.860 (1.060-3.260) Adjusted model

China

Retrospective study

Medical records

339

All confirmed cases of COVID-19 over 60 years old admitted from Jan 1 to Feb 6 at isolation ward of Renmin Hospital of Wuhan University in Wuhan, China which is a designated hospital capable of receiving severe COVID-19 patients.

Of 339 patients identified, the mean age was 71 years, and 173 were female (51%). 60.7% of the patients had comorbidities, while 23.9% had two or more comorbidities.

Median

28 Day


COVID-19 (death)

65

Death due to COVID-19


Comorbidities

Cardiovascular disease

-

Not present

44

286

Present

21

53


Hazard ratio

1.860 (1.060-3.260)

No

Yes

Yes

Multivariate Cox regressions were performed for comorbidities (A) and complications (B), in which the ??Age?? factor was added to correct the models.


Symptoms of dyspnea (HR 2.35, P = 0.001), comorbidities including cardiovascular disease (HR 1.86, P = 0.031) and chronic obstructive pulmonary disease (HR 2.24, P = 0.023), and acute respiratory distress syndrome (HR 29.33, P < 0.001) were strong predictors of death. And a high level of lymphocytes was predictive of better outcome (HR 0.10, P < 0.001).

Average

No