Cai (2020)
Characteristics of Liver Tests in COVID-19 Patients
https://doi.org/10.1016/j.jhep.2020.04.006.
https://www.ncbi.nlm.nih.gov/research/coronavirus/publication/32298767
Findings
Liver test during hospitalization (Cholestatic vs. Normal)
COVID-19 (severe/critical)
Odds ratio: 3.450 (1.250-9.500) Adjusted model

China

Retrospective observational study

Medical records

417

Laboratory-confirmed COVID-19 patients who were admitted to the only referral hospital in Shenzhen, China from January 11 to February 21, 2020 and followed up to March 7, 2020

Age 47 (34-60)y Male 198 (47.5%)

Total

6 Week


COVID-19 (severe/critical)

91

Patients with mild symptoms (i.e., fever, cough, expectoration, and other upper respiratory tract symptoms), and without abnormalities, or with mild changes on chest radiography, were classified as non-severe types. A mild change in chest radiography is defined by multiple small patchy shadows and interstitial changes, mainly in the outer zone of the lung and under the pleura. Severe pneumonia was defined by the presence of any of the following conditions: 1) significantly increased respiration rate (RR): RR ? 30 times/minute; 2) hypoxia: oxygen saturation (resting state) ? 93%; 3) blood gas analysis: partial pressure of oxygen/fraction of inspired oxygen (PaO2) /FiO2)?300 mmHg (millimeters of Mercury); or 4) the occurrence of respiratory or other organ failure that requires intensive care unit (ICU) monitoring and treatment, or shock .


Findings

Liver test during hospitalization

patients were classified as hepatocyte type when the AST/ALT activity was higher than the ALP/GGT activity, and were classified as cholangiocyte type when the reverse occurred

Normal

Cholestatic


Odds ratio

3.450 (1.250-9.500)

No

Yes

Yes

Adjusted for age, sex, epidemiological history, body mass index, liver comorbidity and cough


none

Average

No