Yang (2020)
Predictors for imaging progression on chest CT from coronavirus disease 2019 (COVID-19) patients.
10.18632/aging.102999
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7185104/
Status
Time from symptom onset to hospital admission (>=4 days vs. <4 days)
COVID-19 (severe/critical)
Risk ratio: 0.350 (0.190-0.670) Adjusted model

China

Prospective cohort study

Medical records

273

273 diagnosed COVID-19 patients with mild category in Shanghai Public Health Clinical Center were included in this analysis.

The average age of 273 COVID-19 patients enrolled with imaging progression were older than those without imaging progression (p = 0.006). The optimal cutoff of age for predicting imaging progression on chest CT was 51 years.

Total

7 Day


COVID-19 (severe/critical)

71

71 COVID-19 patients suffered from imaging progression on chest CT at first week after admission, and the other 202 patients were imaging progression-free on chest CT.


Status

Time from symptom onset to hospital admission

COVID-19 patients with period from onset to admission + or - (4) days had lower risk to develop imaging progression on chest CT at first week after admission.

<4 days

>=4 days


Risk ratio

0.350 (0.190-0.670)

Yes

No

Yes

Age, gamma globulin therapy, thymosin therapy, Monocyte-lymphocyte ratio (MLR), serum cystatin C, homocysteine, estimated glomerular filtration rate (eGFR) and period from onset to admission.


Age, MLR, homocysteine and period from onset to admission could predict imaging progression on chest CT from COVID-19

Average

Yes