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Article data
Hamiel (2020)
SARS-CoV-2 Rates in BCG-Vaccinated and Unvaccinated Young Adults
10.1001/jama.2020.8189
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7221856/

Results
Other
Childhood BCG vaccination (Present vs. Not present)
COVID-19 (severe/critical)
Odds ratio: 0.966 (0.060-15.462) Univariate analysis

Study characteristics

Israel

Retrospective observational study

Registry

2967

Persons born from 1979 to 1981 (aged 39-41 years) with those born from 1983 to 1985 (aged 35-37 years). Patient with symptoms that could be compatible with COVID-19 (cough, dyspnea, fever).

50.8% male; mean age, 35 years The BCG vaccine was routinely administered to all newborns in Israel as part of the national immunization program between 1955 and 1982. Overall, the vaccine acceptance rate in Israel is high, with greater than 90% coverage. Since 1982, the vaccine has been administered only to immigrants from countries with high prevalence of tuberculosis.

Total

1 Month


Results

COVID-19 (severe/critical)

2

There was 1 case of severe disease (mechanical ventilation or intensive care unit admission) in each group, and no deaths were reported

Other

Childhood BCG vaccination

BCG vaccine was routinely administered to all newborns in Israel as part of the national immunization program between 1955 and 1982. Since 1982, the vaccine has been administered only to immigrants from countries with high prevalence of tuberculosis.

Not present

1

1458

Present

1

1509

Odds ratio

0.966 (0.060-15.462)

No

No

No

Own calculated odds ratio. Stratified by age: individuals born during the 3 years before and 3 years after cessation of the universal BCG vaccine program.


Other information

Own calculated odds ratio. In conclusion, this study does not support the idea that BCG vaccination in childhood has a protective effect against COVID-19 in adulthood

Average

No

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