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Article data
Lu (2020)
Symptomatic Infection is Associated with Prolonged Duration of Viral Shedding in Mild Coronavirus Disease 2019: A Retrospective Study of 110 Children in Wuhan
https://doi.org/10.1097/inf.0000000000002729
https://pubmed.ncbi.nlm.nih.gov/32379191/

Results
Laboratory Findings
hs-CRP (Abnormal vs. Normal)
COVID-19 in children (any condition)
Odds ratio: 4.890 (1.100-21.750) Adjusted model

Study characteristics

China

Retrospective observational study

Medical records

110

Enrolled 110 children with mild and ordinary COVID-19 who were hospitalized in the confirmed-infection isolation wards at Wuhan Children’s Hospital (Wuhan Maternal and Child Healthcare Hospital), Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China from January 30, 2020, to March 10, 2020.

A total of 110 children - including 81 (73.6%) symptomatic patients and 29 (26.4%) asymptomatic patients. The median age of these patients was 6 years (range, 2 months to 15 years). An approximately 1.2:1.0 male-to-female ratio was found. In symptomatic patients, the most common symptoms were cough and dyspnea (51.8%), followed by fever (50.9%). Notably, 26 (23.6%) patients had digestive symptoms. All patients were administered antiviral therapy, of which interferon-? nebulization was the most frequently used. None of the patients required oxygen therapy.

Total

40 Day


Results

COVID-19 in children (any condition)

81

Symptomatic SARS-COV-2 infection.

Laboratory Findings

hs-CRP

Hypersensitive C-reactive protein. hs-CRP>3.0mg/L

Normal

Abnormal

Odds ratio

4.890 (1.100-21.750)

No

Yes

Yes

In univariate analysis - Age, Lymphocytes, Globulin, Hypersensitive C-reactive protein, Procalcitonin, Interleukin-10, CD4+/CD8+ T cells ratio, Pneumonia. In multivariate analysis (backward selection) - Age, Hypersensitive C-reactive protein and Pneumonia.


Other information

none

Good

Yes

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