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Article data
Cai (2020)
Experimental Treatment with Favipiravir for COVID-19: An Open-Label Control Study
https://doi.org/10.1016/j.eng.2020.03.007
https://www.sciencedirect.com/science/article/pii/S2095809920300631?via%3Dihub

Results
Symptoms
Fever (Present vs. Not present)
COVID-19 (clinical improvement)
Odds ratio: 3.622 (1.054-12.442) Adjusted model

Study characteristics

China

Non-randomized clinical trial

Primary data collection

80

laboratory-confirmed COVID-19 patients

56 patients with laboratory-confirmed COVID-19 were screened, of which 35 were eligible for the FPV arm of the study. A total of 91 laboratory-confirmed COVID-19 patients who had started treatment with LPV/RTV between 24 January and 30 January 2020 were screened, of which 45 were eligible for the control arm of this study.

Total

14 Day


Results

COVID-19 (clinical improvement)

16

A multivariate Cox regression model was used to explore the independent factors affecting viral clearance. The time of viral clearance was set as the TIME variable, viral clearance (0 = no, 1 = yes) was set as the status, and the variables that were significant (P < 0.10) in the univariate Cox analysis or were professionally significant (including age, and whether underlying diseases were present or not) were set as independent variable

Symptoms

Fever

none

Not present

Present

Odds ratio

3.622 (1.054-12.442)

No

Yes

Yes

WBC. Hp, PLT, Neutrophils, T lymphocyte count , CD8+ T lymphocyte , Time from onset to treatment , FPV versus LPV/RTV , Age , Underlying diseases


Other information

none

Average

No

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