Cummings (2020)
Epidemiology, clinical course, and outcomes of critically ill adults with COVID-19 in New York City: a prospective cohort study
Laboratory Findings
D-dimer (1 unit increase vs. Not applicable)
COVID-19 (death)
Hazard ratio: 1.100 (1.010-1.190) Adjusted model

United States of America

Prospective cohort study

Medical records


Prospectively identified adult patients (aged>=18 years) admitted to two NewYork-Presbyterian hospitals from March 2 to April 1, 2020, who were diagnosed with laboratory confirmed COVID-19 and were critically ill with acute hypoxaemic respiratory failure, and collected clinical, biomarker, and treatment data.

The median age of patients was 62 years (51–72), 171 (67%) of 257 patients were men, 159 (62%) were Hispanic or Latino, and 13 (5%) were health-care workers. 212 (82%) patients had at least one chronic illness. 119 (46%) patients had obesity (defined as body-mass index [BMI]>=30), including 39 (71%) of 55 patients who were less than 50 years of age. Patients presented to hospital a median of 5 days (2–7) after symptom onset; black or African American and Hispanic or Latino patients presented later in their illness course than white patients.


28 Day

COVID-19 (death)


in-hospital mortality

Laboratory Findings


D-dimer (ug/mL) (per decile increase)

Not applicable

1 unit increase

Hazard ratio

1.100 (1.010-1.190)




Age, sex, hypertension, chronic cardiac disease, chronic obstructive pulmonary disease or interstitial lung disease, diabetes, Interleukin-6 (per decile increase), D-dimer (per decile increase)