Beigel (2020)
Remdesivir for the Treatment of Covid-19 - Preliminary Report
10.1056/NEJMoa2007764
https://www.nejm.org/doi/full/10.1056/NEJMoa2007764
Treatment
Treatment for COVID-19 (Treated with remdesivir vs. Placebo)
COVID-19 (death)
Hazard ratio: 0.700 (0.470-1.040) Adjusted model

Multicenter

Randomized clinical trial

Primary data collection

1063

Adults hospitalized with Covid-19 with evidence of lower respiratory tract involvement

Age - yr 58.9±15.0; Male sex - no. (%) 684 (64.3) 541 were assigned to the remdesivir group and 522 to the placebo group (Fig. 1). Of those assigned to receive remdesivir, 531 patients (98.2%) received the treatment as assigned. Forty-nine patients had remdesivir treatment discontinued before day 10 because of an adverse event or a serious adverse event other than death (36 patients) or because the patient withdrew consent (13). Of those assigned to receive placebo, 518 patients (99.2%) received placebo as assigned.

Total

29 Day


COVID-19 (death)

81

mortality


Treatment

Treatment for COVID-19

none

Placebo

Treated with remdesivir


Hazard ratio

0.700 (0.470-1.040)

No

No

Yes

baseline ordinal score


none

Average

No