Qi (2020)
Factors associated with duration of viral shedding in adults with COVID-19 outside of Wuhan, China: A retrospective cohort study
https://doi.org/10.1016/j.ijid.2020.05.045
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7231495/pdf/main.pdf
Symptoms
Sputum production (Present vs. Not present)
Prolonged duration of SARS-CoV-2 shedding
Odds ratio: 1.745 (0.448-6.793) Adjusted model

China

Retrospective cohort study

Medical records

147

From January 24th to March 8th, 2020, all patients diagnosed with COVID-19 in Changsha public health treatment center were screened. Changsha public health treatment center is the branch of the first hospital of Changsha that is the only appointed medical institution for the treatment of patients with COVID-19 in Changsha.

The median age was 42 years old (IQR, 35 to 54). The percentage of female gender (54%, 80/147) was slightly higher than that of male gender (46%, 67/147). The median duration of viral shedding in the current study was 17 days (IQR, 12 to 21). The shortest and longest durations were 6 days and 47 days, respectively. It was noted that the proportion declined to 50% about 17 days after symptoms onset. Based on the median as the cut-off point, the study population were further divided into two groups with duration of viral shedding of more than 17 days (n=65) and less than 17 days (n=82). The prolonged duration of viral shedding was defined as the duration more than 17 days.

Total

45 Day


Prolonged duration of SARS-CoV-2 shedding

65

The prolonged duration of viral shedding was defined as the duration more than 17 days. Note : The duration of viral shedding was defined as the number of days from the symptoms onset till the successive negative detection of SARS-CoV-2 RNA.


Symptoms

Sputum production

The action of expectorating, of ejecting phlegm or mucus from the throat or lungs by coughing, hawking, or spitting.

Not present

Present


Odds ratio

1.745 (0.448-6.793)

No

No

Yes

Expectoration, Hemoptysis, Highest temperature (C), Time from symptom onset to admission, partial pressure of oxygen (PaO2), Lymphocyte count, Serum ferritin, treated with glucocorticoids, immunoglobulin, Hospital length of stay.


none

Average

Yes