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Article data
Benussi (2020)
Clinical characteristics and outcomes of inpatients with neurologic disease and COVID-19 in Brescia, Lombardy, Italy
https://doi.org/10.1212/WNL.0000000000009848
https://n.neurology.org/content/neurology/early/2020/05/22/WNL.0000000000009848.full.pdf

Results
Laboratory Findings
LDH (Abnormal vs. Normal)
COVID-19 (death)
Odds ratio: 1.010 (1.000-1.030) Adjusted model

Study characteristics

Italy

Retrospective cohort study

Medical records

56

Two hundred fourteen adult patients (>=18 years old) were hospitalized in the Neurology and Vascular Neurology Unit of the ASST Spedali Civili di Brescia Hospital in Italy from February 21 to April 5, 2020, 56 patients were positive for COVID-19

Patients with COVID-19 were older (77.0, IQR 67.0-83.8 vs 70.1, IQR 52.9-78.6, p=0.006), had a different distribution regarding admission diagnoses particularly for cerebrovascular disorders (n=43, 76.8% vs n=68, 58.1%, p=0.035), and had a higher qSOFA score on admission (0.5, IQR 0.4-0.6 vs 0.9, IQR 0.7-1.1, p=0.006). No significant differences were observed for comorbidities including diabetes, hypercholesterolemia, hypertension, coronary heart disease, chronic kidney disease, immunodeficiency or malignancy (all p>0.050).

Total

45 Day


Results

COVID-19 (death)

21

mortality

Laboratory Findings

LDH

Lactate dehydrogenase (U/L)

Normal

Abnormal

Odds ratio

1.010 (1.000-1.030)

No

Yes

Yes

Age, quick Sequential Organ Failure Assessment. (qSOFA) scores, platelet count, C-reactive protein and lactate dehydrogenase


Other information

Patients with COVID-19 and neurological disease have worse clinical and neurological outcomes, with higher in-hospital mortality rates compared to patients without COVID-19.

Average

Yes

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