Shi (2020)
Clinical Characteristics and Risk Factors for Mortality of COVID-19 Patients With Diabetes in Wuhan, China: A Two-Center, Retrospective Study
Cardiovascular disease (Present vs. Not present)
COVID-19 (death)
Hazard ratio: 1.080 (0.250-4.700) Adjusted model


Retrospective observational study

Medical records


This two-center, retrospective study was conducted at Renmin Hospital of Wuhan University and Zhongnan Hospital of Wuhan University, which are two major tertiary hospitals in Wuhan that serve as government-designated hospitals for the treatment of COVID-19. All the confirmed COVID-19 patients with diabetes who were discharged or died from 1 January 2020 to 8 March 2020 were identified. The patients with diabetes included in our study had a clear diagnosis of diabetes by their physicians on the electronic medical records.

The median age of the patients with diabetes was 64.0 (IQR, 56.0–72.0) years. The patients with and without diabetes were well matched for age and sex, with men and women represented approximately equally. More patients with diabetes reported no exposure history but had a higher prevalence of hypertension (56.9% vs. 28.8%), cardiovascular disease (20.9% vs. 11.1%), and cerebrovascular disease (7.8% vs. 1.3%). Fever and cough were the most common onset of symptoms in both groups. Patients with diabetes were more likely to require intensive care unit (ICU) admission (17.6% vs. 7.8%, P , 0.05).


68 Day

COVID-19 (death)


Mortality of COVID-19 Patients Without Diabetes. Among the included 306 patients, 153 Patients without diabetes. Comparisons between survivors (n=137) and nonsurvivors (n=16) among patients with diabetes. Note : One sex and age-matched COVID-19 patient without diabetes was randomly selected for each patient with diabetes.


Cardiovascular disease

underlying comorbidity

Not present


Hazard ratio

1.080 (0.250-4.700)




Age, sex, Hypertension, Cardiovascular disease, Chronic pulmonary disease

Patients without diabetes (N=153)