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Article data
Bianchetti (2020)
Clinical Presentation of COVID19 in Dementia Patients
https://doi.org/10.1007/s12603-020-1389-1
https://link.springer.com/article/10.1007%2Fs12603-020-1389-1

Results
Complications
Dementia (Present vs. Not present)
COVID-19 (death)
Odds ratio: 1.840 (1.080-3.130) Adjusted model

Study characteristics

Italy

Retrospective cohort study

Medical records

627

627 patients consecutively hospitalized for COVID19 pneumonia in two Italian hospitals (Acute Hospital in Brescia province, Northern Italy)

Age, mean (SD), y 70,7 (12.9); women 335 (53.4%) The mean age of patients diagnosed with dementia was 82.6 (SD 5.3; IQR 80–86), versus 68.9 (SD 12.7; IQR 60–68) in patients not affected by dementia (p<0.001; Student’s t test). Females were 47 (57.3%) among patients with dementia and 288 (52.8%) among patients not diagnosed with dementia, respectively. The mortality rate was 62.2% (51/82) among patients affected by dementia compared to 26.2% (143/545) in subjects without dementia (p<0.001). Dementia was diagosed according to clinical history and results of the cognitive assessment.

Total

46 Day


Results

COVID-19 (death)

194

The mortality rate of hospitalized COVID19 pneumonia patients

Complications

Dementia

Dementia is a group of conditions characterized by impairment of at least two brain functions, such as memory loss and judgement.

Not present

Present

Odds ratio

1.840 (1.080-3.130)

No

Yes

Yes

Age, gender, dementia


Other information

The Clinical Dementia Rating Scale (CDR) (5) was used to determine the severity of dementia: 36 patients (43.4%) were classified in stage 1, 15 (18.3%) in stage 2 and 31 (37.8%) in stage 3. The Mortality rates were, respectively, 41.7%, 66.7%, and 83.9% (p<0.001, one-way ANOVA).

Average

Yes

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