We included 11 reports including 10 cohort studies and 1 randomized clinical trial involving 5249 subjects (2003–2020). Two discussed the association of corticosteroids and virus clearing and 10 explored how corticosteroids impacted mortality, hospitalization duration, use of mechanical ventilation, and a composite endpoint. Risk of bias in the randomized clinical trial was assessed according to the Jadad scale in the following domains: (1) random sequence generation; (2) allocation concealment; (3) blinding of participants and personnel; and (4) completed withdrawals and dropouts.