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Article data
Zhao (2020)
Lymphopenia is associated with severe coronavirus disease 2019 (COVID-19) infections: A systemic review and meta-analysis
https://doi.org/10.1016/j.ijid.2020.04.086
files/e861578c_Lymphopenia is associated with severe coronavirus disease 2019 (COVID-19) infections A systemic review and meta-analysis.pdf

Results
Laboratory Findings
Lymphopenia at hospital admission (Present vs. Not present)
COVID-19 (severe/critical)
Odds ratio: 2.990 (1.310-6.820) Univariate analysis

Study characteristics

China

A systemic review and meta-analysis

Review

2282

13 studies (11 in English and 2 in Chinese)were included in the analysis. Most studies reported the follow-up period inadequately. As a result, the overall quality of literature included in this study was not high, with MINORS scores from 10-13.

The pooled clinical data of 13 studies involving 2282 cases showed that a total of 442 patients required intensive care or ventilatory support, or died. The clinical severity was defined as the composite of ICU admission, use of mechanical ventilation or death as reported in nine studies, death only as reported in two studies and ICU admission as reported in two studies. The blood tests were measured at the time of hospitalization in all studies. Eight studies reported the lymphocyte count and one study only reported information of lymphopenia.

0


Results

COVID-19 (severe/critical)

442

requirement for intensive care, mechanical ventilation or death which is consistent with most articles

Laboratory Findings

Lymphopenia at hospital admission

Lymphopenia was defined as a lymphocyte count of less than 1.1 x109 /L in four studies(Liu et al., 2020a; Liu et al., 2020b; Yang et al., 2020; Zhang et al., 2020), and as less than 1.5 x109 /L in one (Guan W-j et al., 2020).

Not present

Present

Odds ratio

2.990 (1.310-6.820)

No

Yes

No

pooled analysis


Other information

Lymphopenia is a prominent part of severe COVID-19 and a lymphocyte count of less than 1.5 x 10^9/L may be useful in predicting the severity clinical outcomes.

Average

Yes

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