Yin (2020)
Comparison of transmissibility of coronavirus between symptomatic and asymptomatic patients: Reanalysis of the Ningbo Covid-19 data
https://doi.org/10.1101/2020.04.02.20050740
https://www.medrxiv.org/content/10.1101/2020.04.02.20050740v1.full.pdf
Symptoms
Symptomatic SARS COV-2 infection (Present vs. Not present)
SARS COV-2 infection
Odds ratio: 1.568 (0.679-3.620) Univariate analysis

China

Descriptive (Case report/series)

Primary data collection

2050

Reanalysis of the Ningbo Covid-19 Data - Investigate the transmissibility of coronavirus for symptomatic and asymptomatic patients using the Ningbo Covid-19 data.

From January 21st to March 6th 2020, there were 157 symptomatic cases and 30 asymptomatic cases in the Ningbo Covid-19 data. These infected cases resulted in 2147 close contacts with them, among which 2001 exposures were caused by the symptomatic cases and 146 by the asymptomatic cases. The average number of close contacts by the symptomatic cases is 13 and that by the asymptomatic cases is 5, and the difference is statistically significant with a p-value of 6×10^-6 Fisher’s exact tests are used to investigate the difference in the transmission rates between the symptomatic and asymptomatic patients. We consider two scenarios: One combines the numbers of symptomatic and asymptomatic cases as the total number of infected patients, leading to a 2×2 table; and the other separates them, leading to a 2×3 table.

46 Day


SARS COV-2 infection

100

Infected cases. Primary analysis of close contacts by 82 symptomatic and 18 asymptomatic cases.


Symptoms

Symptomatic SARS COV-2 infection

transmission rates through close contacts by symptomatic and asymptomatic cases of Covid-19 with super-spreader cases

Not present

Present


Odds ratio

1.568 (0.679-3.620)

No

No

No

Primary analysis with the estimated rates and 95% confidence intervals. Fisher’s exact tests are used to investigate the difference in the transmission rates between the symptomatic and asymptomatic patients.


none

Average

Yes