The median ages in years (range) were 71 (27–99), 68 (28–95), and 70 (22–99) in the hydroxychloroquine (HC), HC with azithromycin (HC+AZ), and the no HC groups, respectively. In this cohort of 807 patients, 121 (15%) and 67 (8.3%) patients were taking angiotensin converting enzyme inhibitors and angiotensin II receptor blockers, respectively. Among the 807 patients, 198 (24.5%) and 214 (26.5%) patients were treated with HC and HC+AZ, respectively, although 395 (49.0%) patients did not receive HC at any time during their hospitalization. Among the 412 (51.1%) patients who received HC, 355 (86.2%) patients were started on HC treatment before the institution of mechanical ventilation. The median daily doses (interquartile range [IQR]) of HC were 400 (400–480) mg and 422.2 (400–480) mg in the HC and HC+AZ groups, respectively. The median (IQR) durations of treatment with HC were 5 (3–5) days and 5 (4–6) days in the HC and HC+AZ groups, respectively. Of these 807 patients, 124 (15.4%) died, 517 (64.1%) were discharged alive, and 166 (20.6%) remained hospitalized at the end of the study period. The unadjusted mortality rates were 19.2%, 22.9%, and 9.4% in the HC, HC+AZ, and no HC groups, respectively (p < 0.001), in patients who were treated with HC at any time during the hospitalization period.