Li (2020)
The Clinical and Chest CT Features Associated with Severe and Critical COVID-19 Pneumonia
Laboratory Findings
Neutrophil ratio increased (Present vs. Not present)
COVID-19 (severe/critical)
Odds ratio: 9.680 (3.280-28.580) Univariate analysis


Retrospective cohort study

Medical records


Eighty-three patients with COVID-19 pneumonia including 25 severe/critical cases and 58 ordinary cases were enrolled. The chest CT images and clinical data of them were reviewed and compared. The risk factors associated with disease severity were analyzed.

Compared with the ordinary patients, the severe/critical patients had older ages, higher incidence of comorbidities, cough, expectoration, chest pain and dyspnea.


COVID-19 (severe/critical)


COVID-19 (Severe/critical pneumonia): The severe/critical patients met any of the following condition:1) respiratory rate >=30 breaths per minute; 2) finger of oxygen saturation ?93% in a resting state; 3) arteria oxygen tension (PaO2)/inspiratory oxygen fraction (FiO2) <=300 mmHg (1mmHg=0.133kPa); 4) respiratory failure occurred and mechanical ventilation required; 5) shock occurred; 6) patients with other organ failure needed intensive care unit monitoring and treatment.

Laboratory Findings

Neutrophil ratio increased

Count (10^9/L)

Not present


Odds ratio

9.680 (3.280-28.580)




There are significant differences in clinical symptoms, laboratory examinations and CT manifestations between the ordinary patients and the severe/critical patients. Many factors are related to the severity of the disease, which can help clinicians to judge the severity of the patient and evaluate the prognosis.

Investigate the clinical and CT features associated with severe and critical Corona Virus Disease 2019 (COVID-19) pneumonia.