Du (2020)
Predictors of Mortality for Patients with COVID-19 Pneumonia Caused by SARS-CoV-2: A Prospective Cohort Study
https://doi.org/10.1183/13993003.00524-2020
https://erj.ersjournals.com/content/early/2020/04/01/13993003.00524-2020
Laboratory Findings
CD3+CD8+ T cells (Abnormal vs. Normal)
COVID-19 (death)
Odds ratio: 3.980 (1.130-14.010) Adjusted model

China

Prospective cohort study

Medical records

179

179 patients who were hospitalised to Wuhan Pulmonary Hospital between December 25, 2019 and February 7, 2020, of whom 136 (76%) were diagnosed definitely as having COVID-19 pneumonia with positive SARS-CoV-2 test result and the remaining 43 (24%) were diagnosed clinically.

The mean time between onset of symptoms and hospitalisation was 9.7 days (sd, 4.3 days). The mean age was 57.6 years (sd, 13.7 years; range, 18-87 years), and 97 (54.2%) were men. Of 179 patients, 21 (11.7%) worsened in a short period of time and died of multiple organ failure, especially respiratory failure and heart failure, and the mean duration from admission to death was 13.7?days (sd, 8.3 day; rang, 3 - 33 days)

0


COVID-19 (death)

21

Mortality of COVID-19 pneumonia patients


Laboratory Findings

CD3+CD8+ T cells

<=75 cell / uL

Normal

Abnormal


Odds ratio

3.980 (1.130-14.010)

No

Yes

Yes

age group >=65 years, cardiovascular or cerebrovascular diseases, CD3+CD8+ T cells, and cardiac troponin


p value for OR: p<0.001. They identified four risk factors, age >= 65 years, preexisting concurrent cardiovascular or cerebrovascular diseases, CD3+CD8+ T cells <= 75 cell.uL-1, and cardiac troponin I >= 0.05 ngÂ?mL-1, especially the latter two factors, were predictors for mortality of COVID-19 pneumonia patients.

Average

Yes