Wang (2020)
Coronavirus disease 2019 in elderly patients: Characteristics and prognostic factors based on 4-week follow-up
https://doi.org/10.1016/j.jinf.2020.03.019
https://www.ncbi.nlm.nih.gov/pubmed/32240670
Complications
Cardiac injury (Present vs. Not present)
COVID-19 (death)
Hazard ratio: 1.550 (0.750-3.190) Adjusted model

China

Retrospective study

Medical records

339

All confirmed cases of COVID-19 over 60 years old admitted from Jan 1 to Feb 6 at isolation ward of Renmin Hospital of Wuhan University in Wuhan, China which is a designated hospital capable of receiving severe COVID-19 patients.

Of 339 patients identified, the mean age was 71 years, and 173 were female (51%). 60.7% of the patients had comorbidities, while 23.9% had two or more comorbidities.

Median

28 Day


COVID-19 (death)

65

Death due to COVID-19


Complications

Cardiac injury

Cardiac injury was defined if the serum level of cardiac troponin I (cTnI) was above the 99th percentile upper reference limit

Not present

26

269

Present

39

70


Hazard ratio

1.550 (0.750-3.190)

No

No

Yes

Multivariate Cox regressions were performed for comorbidities and complications, in which the ??Age?? factor was added to correct the models.


Complications including acute cardiac injury, arrhythmia, acute kidney injury (AKI), ARDS, cardiac insufficiency and bacterial infection were all predictors of death.

Average

No