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Article data
Chen (2020)
Analysis of myocardial injury in patients with COVID-19 and association between concomitant cardiovascular diseases and severity of COVID-19
https://doi.org/10.3760/cma.j.cn112148-20200225-00123
https://www.ncbi.nlm.nih.gov/pubmed/32141280

Results
Laboratory Findings
Cardiac troponin (1 unit increase vs. Normal)
COVID-19 (severe/critical)
Odds ratio: 26.910 (4.090-177.230) Adjusted model

Study characteristics

China

Cross-sectional study

Medical records

150

150 consecutive patients with COVID-19 in the fever clinic of Tongji Hospital in Wuhan from January to February in 2020, including 126 mild cases and 24 cases in critical care.

Age (59 ? 16) years old (14-96 years old), 84 males (56%). 49 patients with hypertension (32.6%), 9 patients with history of coronary heart disease (6.0%), 20 patients with diabetes (13.3%), 2 patients with arrhythmia (1.3%), 3 cases of malignant tumor (2.0%). Among the selected patients, there were 1 pregnant woman (0.6%) and 2 patients (1.3%) who needed dialysis for renal dysfunction.

0


Results

COVID-19 (severe/critical)

24

COVID-19 patients in critical care

Laboratory Findings

Cardiac troponin

The normal reference for Cardiac troponin-I (cTnI) using 99th percentile of healthy people as upper limit, which is <= 26.3 ng / L

Normal

9

128

1 unit increase

15

22

Odds ratio

26.910 (4.090-177.230)

No

Yes

Yes

Multivariate logistic regression analysis - age, gender, NT-proBNP level, cTnI level, hs-CRP level, serum creatinine level, hypertension and coronary heart disease


Other information

Multivariate logistic regression analysis showed that elevated cTnI(OR=26.909, 95%CI 4.086-177.226, P=0.001) and CHD (OR=16.609, 95%CI 2.288-120.577, P=0.005) were the independent risk factors of critical disease status.

Average

No

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