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Article data
Zhang (2020)
Myocardial injury is associated with in-hospital mortality of confirmed or
https://doi.org/10.1101/2020.03.21.20040121
https://doi.org/10.1101/2020.03.21.20040121

Results
Laboratory Findings
Oxygen Saturation (SpO2) (Abnormal vs. Normal)
COVID-19 (severe/critical)
Hazard ratio: 0.700 (0.550-0.910) Adjusted model

Study characteristics

China

Retrospective cohort study

Medical records

110

Investigate the association between cardiac injury and in-hospital mortality of patients with confirmed or suspected COVID-19.

Demographic, clinical, treatment, and laboratory data of consecutive confirmed or suspected COVID-19 patients admitted in Wuhan No.1 Hospital from 25th December, 2019 to 15th February, 2020 were extracted from electronic medical records and were retrospectively reviewed and analyzed.

Total

10 Day


Results

COVID-19 (severe/critical)

48

COVID-19 (progression): Myocardial injury is associated with in-hospital mortality of confirmed or suspected COVID-19

Laboratory Findings

Oxygen Saturation (SpO2)

Multivariate Cox regression analysis shown that pulse oximetry of oxygen saturation (SpO2) on admission (HR 0.704, 95% CI 0.546-0.909, per 1% decrease, p=0.007)

Normal

Abnormal

Hazard ratio

0.700 (0.550-0.910)

Yes

No

Yes

Cardiac injury defined by hs-cTnI elevation and elevated d-dimer on admission were risk factors for in-hospital death, while higher SpO2 could be seen as a protective factor, which could help clinicians to identify patients with adverse outcome at the early stage of COVID-19.


Other information

investigate the association between cardiac injury and in-hospital mortality of patients with confirmed or suspected COVID-19.

Good

No

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