Chen (2020)
Analysis of myocardial injury in patients with COVID-19 and association between concomitant cardiovascular diseases and severity of COVID-19
Patient characteristics
Age (1 year increase vs. Not applicable)
COVID-19 (severe/critical)
Odds ratio: 1.020 (0.960-1.080) Adjusted model


Cross-sectional study

Medical records


150 consecutive patients with COVID-19 in the fever clinic of Tongji Hospital in Wuhan from January to February in 2020, including 126 mild cases and 24 cases in critical care.

Age (59 ? 16) years old (14-96 years old), 84 males (56%). 49 patients with hypertension (32.6%), 9 patients with history of coronary heart disease (6.0%), 20 patients with diabetes (13.3%), 2 patients with arrhythmia (1.3%), 3 cases of malignant tumor (2.0%). Among the selected patients, there were 1 pregnant woman (0.6%) and 2 patients (1.3%) who needed dialysis for renal dysfunction.


COVID-19 (severe/critical)


COVID-19 patients in critical care

Patient characteristics



Not applicable

1 year increase

Odds ratio

1.020 (0.960-1.080)




Multivariate logistic regression analysis - age, gender, NT-proBNP level, cTnI level, hs-CRP level, serum creatinine level, hypertension and coronary heart disease

Univariate logistic regression analysis showed that age, male, elevated NT-proBNP, elevated cTnI, elevated hs-CRP, elevated serum creatinine, hypertension, and CHD were significantly correlated with critical disease status(all P<0.05). Multivariate logistic regression analysis showed that elevated cTnI(OR=26.909, 95%CI 4.086-177.226, P=0.001) and CHD (OR=16.609, 95%CI 2.288-120.577, P=0.005) were the independent risk factors of critical disease status.