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Article data
Chen (2020)
Analysis of myocardial injury in patients with COVID-19 and association between concomitant cardiovascular diseases and severity of COVID-19
https://doi.org/10.3760/cma.j.cn112148-20200225-00123
https://www.ncbi.nlm.nih.gov/pubmed/32141280

Results
Laboratory Findings
Serum N-terminal pro B-type natriuretic peptide (NT-proBNP) (1 unit increase vs. Normal)
COVID-19 (severe/critical)
Odds ratio: 3.240 (0.620-16.980) Adjusted model

Study characteristics

China

Cross-sectional study

Medical records

150

150 consecutive patients with COVID-19 in the fever clinic of Tongji Hospital in Wuhan from January to February in 2020, including 126 mild cases and 24 cases in critical care.

Age (59 ? 16) years old (14-96 years old), 84 males (56%). 49 patients with hypertension (32.6%), 9 patients with history of coronary heart disease (6.0%), 20 patients with diabetes (13.3%), 2 patients with arrhythmia (1.3%), 3 cases of malignant tumor (2.0%). Among the selected patients, there were 1 pregnant woman (0.6%) and 2 patients (1.3%) who needed dialysis for renal dysfunction.

0


Results

COVID-19 (severe/critical)

24

COVID-19 patients in critical care

Laboratory Findings

Serum N-terminal pro B-type natriuretic peptide (NT-proBNP)

The normal value reference interval of N-terminal pro-B-type natriuretic peptide (NT-proBNP): 5.0 to 97.3 ng /L for 18 to 44 years old, 5.0 to 121.0 ng /L for 45 - 54 years old , 5.0 to 198.0 ng/L f

Normal

0

0

1 unit increase

0

0

Odds ratio

3.240 (0.620-16.980)

No

No

Yes

Multivariate logistic regression analysis - age, gender, NT-proBNP level, cTnI level, hs-CRP level, serum creatinine level, hypertension and coronary heart disease


Other information

Univariate logistic regression analysis showed that age, male, elevated NT-proBNP, elevated cTnI, elevated hs-CRP, elevated serum creatinine, hypertension, and CHD were significantly correlated with critical disease status(all P<0.05). Multivariate logistic regression analysis showed that elevated cTnI(OR=26.909, 95%CI 4.086-177.226, P=0.001) and CHD (OR=16.609, 95%CI 2.288-120.577, P=0.005) were the independent risk factors of critical disease status.

Average

No

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