Feng (2020)
COVID-19 with Different Severity: A Multi-center Study of Clinical Features
https://doi.org10.1164/rccm.202002-0445OC.
https://www.ncbi.nlm.nih.gov/pubmed/32275452
Patient characteristics
Age (>=75 years vs. <75 years)
COVID-19 (death)
Hazard ratio: 6.070 (1.650-22.350) Adjusted model

China

Retrospective descriptive study

Medical records

337

All patients enrolled in this study were diagnosed as COVID-19 according to the diagnostic criteria from the fifth version of the guidelines on the Diagnosis and Treatment of COVID-19 by the National Health Commission of China.

the median age of the patients was 53 years (IQR, 40-64).

Total

36 Day


COVID-19 (death)

16

According to the fifth version of the guidelines on the Diagnosis and Treatment of COVID-19 by the National Health Commission of, COVID-19 severity is classified as follows: 1. Mild type The clinical symptoms are mild with no abnormal radiological findings. 2. Moderate type Fever, cough and other symptoms are presented with pneumonia on chest computed tomography. 3. Severe type The disease is classified as severe if one of the following conditions is met: (1) Respiratory distress, respiratory rate ? 30 per min; (2) Oxygen saturation on room air at rest ? 93%; (3) Partial pressure of oxygen in arterial blood / fraction of inspired oxygen ? 300 mmHg. 4. Critical type One of the following conditions has to be met: (1) Respiratory failure occurs and mechanical ventilation is required; (2) Shock occurs; (3) Patients with other organ dysfunction needing intensive care unit monitoring treatment


Patient characteristics

Age

none

<75 years

>=75 years


Hazard ratio

6.070 (1.650-22.350)

No

Yes

Yes

Age, Lymphocyte count , D-dimer, Creatine Kinase, LDH, Hypertension, Cardiovascular disease, Diabetes


none

Average

No