Simonnet (2020)
High prevalence of obesity in severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) requiring invasive mechanical ventilation.
Patient characteristics
BMI (Overweight (25-29kg/m2) vs. Normal (<25 kg/m2))
COVID-19 (severe/critical)
Odds ratio: 1.690 (0.520-5.480) Adjusted model


Retrospective cohort study

Medical records


Consecutive patients admitted in intensive care for SARS-CoV-2, in a single French center.

SARS-CoV-2 study participants were predominantly males (73%), and their median (IQR) age was 60 (51 to 70) years. All patients were diagnosed with COVID-19 pneumonia according to World Health Organization interim guidance (11) with SARS symptoms characterized by dyspnea, increased respiratory frequency, decreased blood oxygen saturation, and need for oxygen support therapy for at least 6 L/min. Throat swab samples were obtained from all patients at admission and tested using real-time reverse transcriptase??polymerase chain reaction assays as previously described to identify SARS-CoV-2 infection


COVID-19 (severe/critical)


COVID-19 (invasive mechanical ventilation[IMV]): The use of IMV was determined when oxygen therapy (? 10 L/min) with target spO2 (90-94%) was ineffective, and when respiratory rate was above 25/min, with signs of acute respiratory failure, despite maximal oxygen therapy

Patient characteristics


25-30 kg/m2 vs. <25 kg/m2

Normal (<25 kg/m2)

Overweight (25-29kg/m2)

Odds ratio

1.690 (0.520-5.480)




Sex, BMI categories, age, diabetes, dyslipidemia, and hypertension BMI category - Overweight (25-30 kg/m2 vs. <25 kg/m2)

This cohort study showed that obesity is a factor in disease severity of SARS-CoV-2, having greatest impact in patients with a BMI ?35 kg/m2.