China
Retrospective observational study
Medical records
417
Laboratory-confirmed COVID-19 patients who were admitted to the only referral hospital in Shenzhen, China from January 11 to February 21, 2020 and followed up to March 7, 2020
Age 47 (34-60)y Male 198 (47.5%)
Total
6 Week
COVID-19 (severe/critical)
91
Patients with mild symptoms (i.e., fever, cough, expectoration, and other upper respiratory tract symptoms), and without abnormalities, or with mild changes on chest radiography, were classified as non-severe types. A mild change in chest radiography is defined by multiple small patchy shadows and interstitial changes, mainly in the outer zone of the lung and under the pleura. Severe pneumonia was defined by the presence of any of the following conditions: 1) significantly increased respiration rate (RR): RR ? 30 times/minute; 2) hypoxia: oxygen saturation (resting state) ? 93%; 3) blood gas analysis: partial pressure of oxygen/fraction of inspired oxygen (PaO2) /FiO2)?300 mmHg (millimeters of Mercury); or 4) the occurrence of respiratory or other organ failure that requires intensive care unit (ICU) monitoring and treatment, or shock .
Findings
Liver test at hospital admission
patients were classified as hepatocyte type when the AST/ALT activity was higher than the ALP/GGT activity, and were classified as cholangiocyte type when the reverse occurred.
Normal
Cholestatic
Odds ratio
1.750 (0.840-3.640)
No
Yes
Adjusted for age, sex, epidemiological history, body mass index, liver comorbidity and cough
none
Average