Wei (2020)
Risk factors for severe COVID-19: evidence from 167 hospitalized patients in Anhui, China
Patient characteristics
Age (1 year increase vs. Not applicable)
COVID-19 (severe/critical)
Odds ratio: 1.000 (0.960-1.050) Adjusted model



Medical records


Hospitalized patients in Anhui, China

There are 30 severe and 137 non-severe patients. The mean age was 49.03 years in severe patients and 40.83 years in non-severe patients, with a significant difference (p=0.007). There were 95 males (56.89%) and 72 females (43.11%). Among 167 patients, 146 had fever (87.43%), 132 had cough (79.04%) and 61 had shortness of breath (36.53%). The prevalence of shortness of breath was 73.33% in severe patients, which was significantly greater than the 28.47% prevalence in non-severe patients (p<0.001). There were 44 patients (26.35%) with comorbidities, of which 9 had multiple comorbidities (5.39%). Among patients with diabetes, severe cases were significantly more common than in non-severe patients (p<0.001). Compared to non-severe patients, fingertip oxygen saturation decreased significantly in severe patients (p<0.001), which predisposed patients with chronic obstructive pulmonary disease to acute exacerbation.


COVID-19 (severe/critical)


Severe patients

Patient characteristics



Not applicable

1 year increase

Odds ratio

1.000 (0.960-1.050)




Multi-factor logistic regression analysis - age, comorbidity, diabetes, shortness of breath, fingertip oxygen saturation, lymphocytes, lymphocyte percentage, albumin, CRP, NLR, CD4 cell count, CD8 cell count, LDH, IL-6, Fibrinogen

The similarities and differences between severe and non-severe patients in this letter suggested that elderly patients with multiple comorbidities, hypoxia, decreased CD4 and CD8 cell counts and increased levels of CRP and IL-6 are all closely associated with disease severity and prognosis, which should be assessed seriously during diagnosis and treatment