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Article data
Colombi (2020)
Well-aerated Lung on Admitting Chest CT to Predict Adverse Outcome in COVID-19 Pneumonia
https://doi.org/10.1148/radiol.2020201433
https://www.ncbi.nlm.nih.gov/research/coronavirus/publication/32301647

Results
Laboratory Findings
LDH (Abnormal vs. Normal)
COVID-19 (severe/fatal)
Odds ratio: 2.300 (1.100-4.600) Adjusted model

Study characteristics

Italy

Retrospective observational study

Medical records

236

Consecutive patients with suspected COVID-19 interstitial pneumonia who underwent chest CT at emergency department admission between February 17 to March 10, 2020.

The study included 236 patients (median age, 68 years old; 95%CI, 66-70 years old), 59/236 (25%, 95%CI: 19% to 31%) were females. All the patients performed reversetranscription polymerase chain reaction (RT-PCR) for SARS-CoV-2 in nasal-pharyngeal swabs. However, a rapid (minutes to hours) COVID-19 RT-PCR test result was not available at our center during this interval. Therefore, chest CT was performed based on high clinical suspicion in addition to clinical and laboratory findings consistent with COVID-19 in the setting of high pre-test probability (i.e., high community disease burden) of COVID-19

0


Results

COVID-19 (severe/fatal)

108

Patients were admitted to the ICU or who died (ICU/death) versus those patients who were discharged from the hospital alive without ICU admission. The time between CT and ICU admission or death was also registered. Visual and software-based quantification of well aerated lung parenchyma on admission chest CT were predictors of intensive care unit (ICU) admission or death in patients with COVID-19 pneumonia.

Laboratory Findings

LDH

median value of the lactate dehydrogenase (LDH, 347 U/L; 95% CI, 325 to 376 U/L)

Normal

Abnormal

Odds ratio

2.300 (1.100-4.600)

No

Yes

Yes

Age, comorbidities - Cardiovascular diseases, SpO2, platelet, C-reactive protein and well-aerated lung parenchyma absolute volume, eGFR, LDH, adipose tissue area measured at T7-T8 level.


Other information

Both visual and software-based quantification of the well aerated lung on chest CT obtained in the emergency setting were independent predictors of ICU admission or death in patients with COVID-19. Quantitative assessment of the extent of lung involvement by COVID-19 pneumonia may be useful for routine patient management. Age group modified by curator for pooled analysis.

Good

Yes

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