Aggarwal (2020)
Cerebrovascular disease is associated with an increased disease severity in patients with Coronavirus Disease 2019 (COVID-19): A pooled analysis of published literature
10.1177/1747493020921664
https://journals.sagepub.com/doi/10.1177/1747493020921664
Comorbidities
Cerebrovascular disease (Present vs. Not present)
COVID-19 (severe/critical)
Odds ratio: 2.550 (1.180-5.510) Univariate analysis

Review

Review

Literature review

1829

Confirmed COVID-19 patients, 6 articles were reviewed

Guan WJ, Ni ZY, Hu Y, et al. Clinical characteristics of coronavirus disease 2019 in China. N Engl J Med 2020. Epub ahead of print 28 February 2020. DOI: 10.1056/ NEJMoa2002032. Qin C, Zhou L, Hu Z, et al. Dysregulation of immune response in patients with COVID-19 in Wuhan, China. Clin Infect Dis 2020. Epub ahead of print. 12 March 2020. DOI: 10.1093/cid/ciaa248. 7. Ruan Q, Yang K, Wang W, Jiang L and Song J. Clinical predictors of mortality due to COVID-19 based on an analysis of data of 150 patients from Wuhan, China. Intensive Care Med 2020. Epub ahead of print. 3 March 2020. DOI: 10.1007/s00134-020-05991-x. 8. Wang D, Hu B, Hu C, et al. Clinical characteristics of 138 hospitalized patients with 2019 novel coronavirusinfected pneumonia in Wuhan, China. JAMA 2020. Epub ahead of print. 7 February 2020. DOI: 10.1001/ jama.2020.1585. 9. Yang X, Yu Y, Xu J, et al. Clinical course and outcomes of critically ill patients with SARS-CoV-2 pneumonia in Wuhan, China: a single-centered, retrospective, observational study. Lancet Respir Med 2020. Epub ahead of print. 24 February 2020. DOI: 10.1016/S2213- 2600(20)30079-5

0


COVID-19 (severe/critical)

553

not defined


Comorbidities

Cerebrovascular disease

none

Not present

Present


Odds ratio

2.550 (1.180-5.510)

No

Yes

No

pooled odds ratio


none

Poor

No