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Article data
Zhang (2020)
Predictive factors for disease progression in hospitalized patients with coronavirus disease 2019 in Wuhan, China
https://doi.org/10.1016/j.jcv.2020.104392
https://www.sciencedirect.com/science/article/pii/S1386653220301347

Results
Comorbidities
Any comorbidity (Present vs. Not present)
COVID-19 (severe/fatal)
Odds ratio: 52.600 (3.600-776.400) Adjusted model

Study characteristics

China

Retrospective cohort study

Medical records

111

The laboratory-confirmed patients with COVID-19 admitted to Union Hospital, Tongji Medical College, Huazhong University of Science and Technology from January 13 to February 16 in 2020 were enrolled.

The median age was 38.0 years (IQR, 32.0–57.0), and 46 (41.4 %) patients were males. 33.3 % of patients had at least one comorbidity (hypertension, diabetes, chronic obstructive pulmonary disease, malignancy, and chronic liver disease). The most common symptoms on admission were fever (71.2 %), cough (37.8 %), fatigue (18.0 %), and dyspnea (16.2 %). Symptoms including diarrhea (9.0 %), pharyngalgia (6.3 %), myalgia (6.3 %), and headache (3.6 %) were rare.

0


Results

COVID-19 (severe/fatal)

18

The primary outcome was the disease deterioration, including the transfer from isolation ward to ICU and all-cause death. The included patients were divided into two groups according to their clinical outcomes: group with favorable prognosis (discharge after recovery) and group with poor prognosis (disease deterioration).

Comorbidities

Any comorbidity

Comorbidity: hypertension, coronary heart disease, diabetes, cerebrovascular disease, chronic obstructive pulmonary disease, chronic hepatitis, and cancer

Not present

Present

Odds ratio

52.600 (3.600-776.400)

No

Yes

Yes

Male gender, comorbidity, lymphopenia, and elevated CRP


Other information

none

Average

Yes

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