Zhang (2020)
Predictive factors for disease progression in hospitalized patients with coronavirus disease 2019 in Wuhan, China
https://doi.org/10.1016/j.jcv.2020.104392
https://www.sciencedirect.com/science/article/pii/S1386653220301347
Complications
Lymphopenia (Present vs. Not present)
COVID-19 (severe/fatal)
Odds ratio: 17.300 (1.100-261.800) Adjusted model

China

Retrospective cohort study

Medical records

111

The laboratory-confirmed patients with COVID-19 admitted to Union Hospital, Tongji Medical College, Huazhong University of Science and Technology from January 13 to February 16 in 2020 were enrolled.

The median age was 38.0 years (IQR, 32.0–57.0), and 46 (41.4 %) patients were males. 33.3 % of patients had at least one comorbidity (hypertension, diabetes, chronic obstructive pulmonary disease, malignancy, and chronic liver disease). The most common symptoms on admission were fever (71.2 %), cough (37.8 %), fatigue (18.0 %), and dyspnea (16.2 %). Symptoms including diarrhea (9.0 %), pharyngalgia (6.3 %), myalgia (6.3 %), and headache (3.6 %) were rare.

0


COVID-19 (severe/fatal)

18

The primary outcome was the disease deterioration, including the transfer from isolation ward to ICU and all-cause death. The included patients were divided into two groups according to their clinical outcomes: group with favorable prognosis (discharge after recovery) and group with poor prognosis (disease deterioration).


Complications

Lymphopenia

Lymphopenia: leukocyte count less than 1.1 G/L

Not present

Present


Odds ratio

17.300 (1.100-261.800)

No

Yes

Yes

Male gender, comorbidity, lymphopenia, and elevated CRP


none

Average

Yes