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Article data
Yan (2020)
Role of Drugs Affecting the Renin-Angiotensin-Aldosterone System on Susceptibility and Severity of COVID-19: A Large Case-Control Study from Zheijang Province, China.
https://doi.org/10.1101/2020.04.24.20077875
https://www.medrxiv.org/content/10.1101/2020.04.24.20077875v1

Results
Treatment
Concomitant medication (Treated with aspirin vs. Not received)
COVID-19 (severe/critical)
Odds ratio: 0.510 (0.120-2.130) Adjusted model

Study characteristics

China

Retrospective observational study

Medical records

610

Consecutive patients presenting to 14 hospitals in Zhejiang province with confirmed COVID-19 by positive RT-PCR assay

A total of 610 COVID- 19 patients were enrolled after admission from various centers in the Zheijiang province (Figure 1). A population-based cohort from the Zhejiang province consisting of 48,667 adults with health records was used as controls. The descriptive characteristics, comorbidities and use of medication available in both cases and controls were compared

0


Results

COVID-19 (severe/critical)

128

This study combined severe and critical into a severe category. Severe type: patients presenting with any one item of the following: (a) respiratory distress, respiratory rate ? 30/min, (b) oxygen saturation of finger ? 93% in resting condition, and (c) arterial partial pressure of oxygen (PaO2) /oxygen concentration (FiO2) ? 300 mmHg (1 mmHg = 0.133 kPa). Critical type: patients meeting any one of the following criteria: (a) respiratory failure requiring mechanical ventilation, (b) shock and (c) requiring ICU admission requirement due to multiple organ failure.

Treatment

Concomitant medication

none

Not received

Treated with aspirin

Odds ratio

0.510 (0.120-2.130)

No

No

Yes

age, sex and BMI


Other information

none

Average

No

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