Klok (2020)
Incidence of thrombotic complications in critically ill ICU patients with COVID-19
https://doi.org/10.1016/j.thromres.2020.04.013
https://pubmed.ncbi.nlm.nih.gov/32291094/
Complications
Coagulopathy (Present vs. Not present)
COVID-19 (severe/critical)
Hazard ratio: 4.100 (1.900-9.100) Adjusted model

the Netherlands

Retrospective observational study

Medical records

184

Patients with proven COVID-19 pneumonia admitted to the ICU between March 7th and April 5th 2020

Age (Mean, standard deviation) 64 (12) Male sex (number, %) 139 (76) Body weight (mean, standard deviation) 87 (16)

Median

7 Day


COVID-19 (severe/critical)

57

composite outcome of symptomatic acute pulmonary embolism (PE), deep-vein thrombosis, ischemic stroke, myocardial infarction or systemic arterial embolism in all COVID-19 patients


Complications

Coagulopathy

coagulopathy, defined as spontaneous prolongation of the prothrombin time > 3 s or activated partial thromboplastin time > 5 s

Not present

Present


Hazard ratio

4.100 (1.900-9.100)

No

Yes

Yes

not defined


CI is incorrect in the article

Poor

No